The school system is comprised of five campuses which are located in 3 regions of the county - South (East Brunswick) North East (Perth Amboy & Woodbridge) North West (Piscataway & Edison).
East Brunswick - 112 Rues Lane East Brunswick, New Jersey 08816
Edison - Academy for Science, Mathematics and Engineering Technologies on the campus of Middlesex CountyCollege. 100 Technology Drive Edison, New Jersey 08820
Perth Amboy - 457 High Street Perth Amboy, NJ 08861
Piscataway - 21 Suttons Lane Piscataway, NJ 08854
Woodbridge - Middlesex County Academy for Allied Health and Biomedical Sciences. 1 Convery Blvd. Woodbridge, NJ 07095